SYNTHESIS OF AZOLYLALKYLQUINOLINES WITH CYTOTOXIC ACTIVITY

Authors
ABEL MD LUU HT MICETICH RG NGUYEN DQ ORESKI AB TEMPEST ML DANESHTALAB M
Citation
Md. Abel et al., SYNTHESIS OF AZOLYLALKYLQUINOLINES WITH CYTOTOXIC ACTIVITY, Journal of heterocyclic chemistry, 33(2), 1996, pp. 415-420
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
33
Issue
2
Year of publication
1996
Pages
415 - 420
Database
ISI
SICI code
0022-152X(1996)33:2<415:SOAWCA>2.0.ZU;2-E
Abstract
The syntheses of various azolylalkylquinoline derivatives in which the nature of the linkage between the quinoline and azolylalkyl moieties of the molecule were altered are described. The compounds were tested for cytotoxic activity towards cancer cells and compound 27 was found to exhibit moderate in vivo activity in a murine sarcoma model.