S. Guccione et al., SYNTHESIS OF 3-METHYL-SUBSTITUTED PYRAZOLOTRIAZOLOPYRIMIDIN-4-ONE ANDPYRAZOLOTHIAZOLOPYRIMIDIN-4-ONE DERIVATIVES, Journal of heterocyclic chemistry, 33(2), 1996, pp. 459-463
As a part of a research on anti-inflammatory analgesic compounds 3-met
hyl substituted pyrazolotriazolopyrimidin-4-one and pyrazolothiazolopy
rimidin-4-one derivatives were prepared by previously reported procedu
res. None of the compounds showed improved activity when compared with
the previously reported unsubstituted analogs.