NUCLEAR-LOCALIZATION OF FUNCTIONAL FGF RECEPTOR-1 IN HUMAN ASTROCYTESSUGGESTS A NOVEL MECHANISM FOR GROWTH-FACTOR ACTION

Authors
STACHOWIAK MK MAHER PA JOY A MORDECHAI E STACHOWIAK EK
Citation
Mk. Stachowiak et al., NUCLEAR-LOCALIZATION OF FUNCTIONAL FGF RECEPTOR-1 IN HUMAN ASTROCYTESSUGGESTS A NOVEL MECHANISM FOR GROWTH-FACTOR ACTION, Molecular brain research, 38(1), 1996, pp. 161-165
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
38
Issue
1
Year of publication
1996
Pages
161 - 165
Database
ISI
SICI code
0169-328X(1996)38:1<161:NOFFRI>2.0.ZU;2-2
Abstract
Fractionation of human astrocytes revealed the presence of 103, 118, a nd 145 kDa forms of FGF receptor 1 (FGFR1) in isolated nuclei. Only tr ace amounts of FGFR1 proteins were detected in the cell membrane or cy toplasmic fractions. Nuclear FGFR1 is found in the nucleoplasm and nuc lear matrix but not in chromatin. Immuno-confocal microscopy further d emonstrates the intranuclear presence of FGFR1 and its colocalization with FGF-2. Nuclear FGFR1 binds to FGF-2 and has tyrosine kinase activ ity. Translocation of functional growth factor receptors into the cell nucleus offers a novel mechanism for growth factor action.