RNA VIRUS EVOLUTION VIA A FITNESS-SPACE MODEL

Authors
TSIMRING LS LEVINE H KESSLER DA
Citation
Ls. Tsimring et al., RNA VIRUS EVOLUTION VIA A FITNESS-SPACE MODEL, Physical review letters, 76(23), 1996, pp. 4440-4443
Citations number
17
Categorie Soggetti
Physics
Journal title
Physical review letters → ACNP
ISSN journal
00319007
Volume
76
Issue
23
Year of publication
1996
Pages
4440 - 4443
Database
ISI
SICI code
0031-9007(1996)76:23<4440:RVEVAF>2.0.ZU;2-R
Abstract
We present a mean-field theory for the evolution of RNA virus populati ons. The theory operates with a distribution of the population in a on e-dimensional fitness space, and is valid for sufficiently smooth fitn ess landscapes. Our approach explains naturally the recent experimenta l observation [L. S. Novella et al., Proc. Natl. Acad. Sci. U.S.A. 92, 5841-5844 (1995)] of two distinct stages in the growth of virus fitne ss.