VALIDATION OF A CAPILLARY ELECTROPHORESIS METHOD FOR THE ENANTIOMERICPURITY TESTING OF ROPIVACAINE, A NEW LOCAL-ANESTHETIC COMPOUND

Authors
SANGERVANDEGRIEND CE GRONINGSSON K
Citation
Ce. Sangervandegriend et K. Groningsson, VALIDATION OF A CAPILLARY ELECTROPHORESIS METHOD FOR THE ENANTIOMERICPURITY TESTING OF ROPIVACAINE, A NEW LOCAL-ANESTHETIC COMPOUND, Journal of pharmaceutical and biomedical analysis, 14(3), 1996, pp. 295-304
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
14
Issue
3
Year of publication
1996
Pages
295 - 304
Database
ISI
SICI code
0731-7085(1996)14:3<295:VOACEM>2.0.ZU;2-U
Abstract
A capillary electrophoresis method for the determination of the enanti omeric purity of ropivacaine, a new local anaesthetic compound develop ed by Astra Pain Control AB, has been validated. The method showed the required limit of quantitation of 0.1% enantiomeric impurity and prov ed to be robust. Good performances were also shown for specificity, li nearity, system repeatability and accuracy. The same capillary electro phoresis method can also be used to simultaneously chirally resolve ho mologues and impurities of ropivacaine.