HEPATITIS-A VIRUS ADAPTATION TO NONPRIMAT E CELLS

Authors
BYCHENKO AB TENTSOV YY ARTYOMOV YK SKOVORODKA VV KHIZHNYAKOVA TM
Citation
Ab. Bychenko et al., HEPATITIS-A VIRUS ADAPTATION TO NONPRIMAT E CELLS, Voprosy virusologii, 41(2), 1996, pp. 58-61
Citations number
25
Categorie Soggetti
Virology
Journal title
Voprosy virusologii → ACNP
ISSN journal
05074088
Volume
41
Issue
2
Year of publication
1996
Pages
58 - 61
Database
ISI
SICI code
0507-4088(1996)41:2<58:HVATNE>2.0.ZU;2-W
Abstract
Hepatitis A virus (HAV) was adapted to nonprimate BHK-21 cell line (Sy rian hamster kidney). Enzyme immunoassay, immunoblotting, and slot hyb ridization demonstrated the capacity of HM175 culture strain to stable reproduction in this cell line. More than 50 passages of adapted HAV were carried out, which showed no changes in the basic cultural charac teristics of the virus. The data permit a conclusion on the possibilit y of HAV reproduction in nonprimate cells.