THERAPY OF EXPERIMENTAL HERPESVIRUS-INFEC TION WITH NONSTEROID ANTIINFLAMMATORY DRUGS

Authors
YEVSTROPOV AN YAVOROVSKAYA VY GALEGOV GA
Citation
An. Yevstropov et al., THERAPY OF EXPERIMENTAL HERPESVIRUS-INFEC TION WITH NONSTEROID ANTIINFLAMMATORY DRUGS, Voprosy virusologii, 41(2), 1996, pp. 66-70
Citations number
34
Categorie Soggetti
Virology
Journal title
Voprosy virusologii → ACNP
ISSN journal
05074088
Volume
41
Issue
2
Year of publication
1996
Pages
66 - 70
Database
ISI
SICI code
0507-4088(1996)41:2<66:TOEHTW>2.0.ZU;2-C
Abstract
The therapeutic effect of nonsteroid antiinflammatory drugs (pyrazolon e and salicylate derivatives) and their combinations with acyclovir wa s assessed in experimental herpesvirus infection in cell culture and i n mice. A combination of 4-iodantipyrine and acyclovir protected mice from herpesvirus encephalitis. This effect was associated with a decre ase of the level of the virus in mouse brain and an increase of the ti ters of serum interferon and virusneutralizing antibodies.