TREND OF INCREASING LEVELS OF MINIMUM INHIBITORY CONCENTRATION OF CIPROFLOXACIN TO SALMONELLA-TYPHI

The minimum Inhibitory concentration (MIG) of ciprofloxacin has been d etermined in 193 strains of S. typhi isolated during January and July each year from March 1991 to July 1995, While all strains remained wit hin established range of susceptibility, a clear trend of increase of MIC values with time was observed, During the first four study periods , all strains had MIC values below 0.031 mu g/ml; during the fifth and sixth, 3 strains had a higher value namely 0.125 mu g/ml. During the last four, 14 strains showed MTC values of 0.25 mu g/ml. Thus an incre ase in MIC of ciprofloxacin to S. typhi has been observed over the yea rs.