R. Chandrasekaran et Pb. Murthy, MOLECULAR ABNORMALITIES OF BCR GENE IN SOME INDIAN PATIENTS WITH CHRONIC MYELOID-LEUKEMIA, INDIAN JOURNAL OF MEDICAL RESEARCH, 103, 1996, pp. 267-271
The DNAs from 7 unselected Philadelphia chromosome-positive (Ph') chro
nic myeloid leukaemia (CML) patients were analysed for the distributio
n of breakpoints in the breakpoint cluster region (bcr) gene by Southe
rn blot. Breakpoints were detected between the regions of exons '2' an
d '4' of the bcr gene in 5 out of 7 patients. In two patients, breakpo
ints occurred around exon 4 of the bcr gene. This study presents some
information on the nature of breakpoint distribution in the bcr gene o
f Indian CML patients.