MOLECULAR ABNORMALITIES OF BCR GENE IN SOME INDIAN PATIENTS WITH CHRONIC MYELOID-LEUKEMIA

Citation
R. Chandrasekaran et Pb. Murthy, MOLECULAR ABNORMALITIES OF BCR GENE IN SOME INDIAN PATIENTS WITH CHRONIC MYELOID-LEUKEMIA, INDIAN JOURNAL OF MEDICAL RESEARCH, 103, 1996, pp. 267-271
Citations number
19
Categorie Soggetti
Medicine, General & Internal",Immunology
ISSN journal
09715916
Volume
103
Year of publication
1996
Pages
267 - 271
Database
ISI
SICI code
0971-5916(1996)103:<267:MAOBGI>2.0.ZU;2-G
Abstract
The DNAs from 7 unselected Philadelphia chromosome-positive (Ph') chro nic myeloid leukaemia (CML) patients were analysed for the distributio n of breakpoints in the breakpoint cluster region (bcr) gene by Southe rn blot. Breakpoints were detected between the regions of exons '2' an d '4' of the bcr gene in 5 out of 7 patients. In two patients, breakpo ints occurred around exon 4 of the bcr gene. This study presents some information on the nature of breakpoint distribution in the bcr gene o f Indian CML patients.