MOLECULAR ABNORMALITIES OF BCR GENE IN SOME INDIAN PATIENTS WITH CHRONIC MYELOID-LEUKEMIA

The DNAs from 7 unselected Philadelphia chromosome-positive (Ph') chro nic myeloid leukaemia (CML) patients were analysed for the distributio n of breakpoints in the breakpoint cluster region (bcr) gene by Southe rn blot. Breakpoints were detected between the regions of exons '2' an d '4' of the bcr gene in 5 out of 7 patients. In two patients, breakpo ints occurred around exon 4 of the bcr gene. This study presents some information on the nature of breakpoint distribution in the bcr gene o f Indian CML patients.