CONFORMATIONAL RESTRICTED 3-METHYL-2-PHEN YLPIPERAZINES - SYNTHESIS OF 2,3,4,4A,9,9A-HEXAHYDRO-1H-INDENO[1,2-B]PYRAZINES - POTENTIAL ANTIDEPRESSANTS

Authors
CHAHBOUN S GELBCKE M VANDEVLIEDT G SMITH DF
Citation
S. Chahboun et al., CONFORMATIONAL RESTRICTED 3-METHYL-2-PHEN YLPIPERAZINES - SYNTHESIS OF 2,3,4,4A,9,9A-HEXAHYDRO-1H-INDENO[1,2-B]PYRAZINES - POTENTIAL ANTIDEPRESSANTS, Bulletin des Societes chimiques belges, 105(5), 1996, pp. 287-296
Citations number
22
Categorie Soggetti
Chemistry
Journal title
Bulletin des Societes chimiques belges → ACNP
ISSN journal
00379646
Volume
105
Issue
5
Year of publication
1996
Pages
287 - 296
Database
ISI
SICI code
0037-9646(1996)105:5<287:CR3Y-S>2.0.ZU;2-2
Abstract
The synthesis of various diastereoisomeric (+/-) trans- (VIII) and cis -2,3,4,4a,9,9a-hexahydro-1H-indeno[1,2-b] pyrazines (IX) is described, using as key step for piperazine ring formation an alkoxyphosphonium salt. Compound VIIIa was prepared as a potential serotonin reuptake in hibitor.