CORONARY ARTERIOGRAPHY WITH AN OXYGENATED CONTRAST-MEDIUM - CARDIAC EFFECTS IN DOGS WITH AND WITHOUT ACUTE ISCHEMIC HEART-FAILURE

Rationale and Objectives. We investigated the possible cardiac effects of oxygen addition to contrast media (CM) during coronary arteriograp hy in dogs that did and did not have ischemic heart failure. Methods. Acute ischemic heart failure was induced by injecting small plastic mi crospheres into the left coronary artery of 18 dogs. Hemodynamic and e lectrophysiologic measurements were performed during a single injectio n before and during heart failure and during a single injection and fi ve rapidly repeated CM injections during heart failure. Iohexol supple mented with electrolytes (iohexol + electrolytes = IPE), oxygenated IP E (IPE+O), Ringer acetate, and oxygenated Ringer acetate were injected into the left coronary artery. Results. Single injections of IPE and IPE+O induced small hemodynamic and electrophysiologic effects. Howeve r, repeated injections of IPE and IPE+O increased left ventricular ino tropy (maximum value of the first derivative of the left ventricular p ressure) by 36% and 39%, reduced heart rate by 7% (for both), and leng thened QT(c) time (corrected QT interval) by 39 and 38 msec, respectiv ely. A comparison of IPE and IPE+O revealed no statistically significa nt differences. Conclusion. Although electrolyte addition to nonionic CM may reduce the risk of cardiac complications during coronary arteri ography, oxygenation does not seem to significantly further reduce thi s risk.