ARACHIDONIC-ACID METABOLISM AND CELL-PROLIFERATION IN RAT MAMMARY-CARCINOMA CELLS TREATED WITH INDOMETHACIN

Authors
TRIPATHI SC VOSSELLER KA MCCORMICK DL
Citation
Sc. Tripathi et al., ARACHIDONIC-ACID METABOLISM AND CELL-PROLIFERATION IN RAT MAMMARY-CARCINOMA CELLS TREATED WITH INDOMETHACIN, Biochimica et biophysica acta. Molecular basis of disease, 1316(1), 1996, pp. 5-7
Citations number
21
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular basis of disease → ACNP
ISSN journal
09254439
Volume
1316
Issue
1
Year of publication
1996
Pages
5 - 7
Database
ISI
SICI code
0925-4439(1996)1316:1<5:AMACIR>2.0.ZU;2-N
Abstract
To determine the specificity of action of indomethacin as an inhibitor of cyclooxygenase in the mammary epithelium, cell proliferation and l evels of PGE(2) and LTB(4) were quantitated in 13762 MAT rat mammary c arcinoma cells treated with 10(-4) to 10(-10) M concentrations of drug . Suppression of proliferation of 13762 MAT cells by indomethacin was associated with reduced levels of both PGE(2) and LTB(4). The antiprol iferative activity of indomethacin in rat mammary carcinoma cells may be modulated through inhibition of both cyclooxygenase and lipoxygenas e pathways of arachidonic acid metabolism.