PLACENTAL-TRANSFER OF (H-3)-GM1 AND ITS DISTRIBUTION TO MATERNAL AND FETAL TISSUES OF THE RAT

Authors
HUNGUND BL MORISHIMA HO GOKHALE VS COOPER TB
Citation
Bl. Hungund et al., PLACENTAL-TRANSFER OF (H-3)-GM1 AND ITS DISTRIBUTION TO MATERNAL AND FETAL TISSUES OF THE RAT, Life sciences, 53(2), 1993, pp. 113-119
Citations number
24
Categorie Soggetti
Biology,"Medicine, Research & Experimental
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
53
Issue
2
Year of publication
1993
Pages
113 - 119
Database
ISI
SICI code
0024-3205(1993)53:2<113:PO(AID>2.0.ZU;2-1
Abstract
The demonstration that ganglioside GM1 pretreatment reduced the ethano l induced neurobehavioral effects in adult pups exposed to ethanol in utero, prompted study to examine whether GM1 crosses the placenta and penetrates fetal tissues. The present results indicate that H-3-galact ose labeled GM1 not only passes the placenta but also served as a subs trate for the synthesis of polysialogangliosides, and remained in vari ous tissues up to 48 h after maternal (H-3)-GM1 administration.