DESIGN OF CONFORMATIONALLY RIGID DIMERIC MRI AGENTS

Authors
SHUKLA R FERNANDEZ M PILLAI RK RANGANATHAN R RATSEP PC ZHANG X TWEEDLE MF
Citation
R. Shukla et al., DESIGN OF CONFORMATIONALLY RIGID DIMERIC MRI AGENTS, Magnetic resonance in medicine, 35(6), 1996, pp. 928-931
Citations number
19
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Magnetic resonance in medicine → ACNP
ISSN journal
07403194
Volume
35
Issue
6
Year of publication
1996
Pages
928 - 931
Database
ISI
SICI code
0740-3194(1996)35:6<928:DOCRDM>2.0.ZU;2-E
Abstract
The conformational flexibility of the linkage mechanism or tether betw een paramagnetic metal centers is explored to assess optimal structura l characteristics of multimeric MRI contrast agents. Two dimeric param agnetic chelates differing in linkage flexibility but similar in symme try are compared. Relaxivity, water hydration number, and reorientatio nal times of the chelate groups are obtained, and the results demonstr ate that greater linkage flexibility reduces overall relaxivity.