ANTIBODY-MIMICKING POLYMERS AS CHIRAL STATIONARY PHASES IN HPLC

Antibody-mimicking synthetic polymers, selective for various optically active amino acid derivatives and pcp tides, were prepared by noncova lent molecular imprinting, A novel approach, in which the branched, tr ifunctional cross-linkers pentaerythritol triacrylate and 2,2-bis(hydr oxymethyl)butanol trimethacrylate were copolymerized with methacrylic acid, is described. The polymers were subsequently applied as chiral s tationary phases in high-performance liquid chromatography. They were superior to previously reponed noncovalent molecularly imprinted polym ers used for chiral separations in that they showed considerably highe r load capacity, increased selectivity, and better resolving capabilit y.