APPLICATION OF PHOTOBACTERIUM-PHOSPHOREUM TO TOXICITY ASSESSMENT OF PHENYLTHIO-CARBOXYLATES

Acute toxicities (15min-EC(50)) of 18 phenylthio-carboxylates to Photo bacterium phosphoreum were detemined. A quantitative structure-activit y relationship was developed based on Hansch's equation, which showed that the toxicity is influenced mainly by the lipophility and electron ic effects. The toxic ratio values were calculated from these experime ntal and the predicted EC(50) (baseline toxicity) from the octanol/wat er partition coefficients, which showed that these compounds are belon g to nonspecifically acting chemicals, and the possible mode of toxic action to Photobacterium phosphoreum is discussed. Copyright (C) 1996 Elsevier Science Ltd