M. Tanaka et al., CLINICAL MANIFESTATIONS IN 100 JAPANESE BULLOUS PEMPHIGOID CASES IN RELATION TO AUTOANTIGEN PROFILES, Clinical and experimental dermatology, 21(1), 1996, pp. 23-27
The relationship between clinical findings and antigen profiles in 100
bullous pemphigoid (BP) patients has been investigated. The patients
were divided into four groups based upon the results of immunoblot ana
lysis, namely patients whose sera detected the 230-kDa BP antigen (BP2
30) and the 180-kDa BP antigen (BP180), those recognizing either BP230
or BP180 alone, and those recognizing neither antigen. Analysis by th
e chi-squared test showed predominant occurrence of oral (P < 0.05) an
d facial lesions (P < 0.005) in patients whose sera detected BP180, an
d these patients also tended to have more extensive lesions (P < 0.005
). Patients that were positive for BP180 alone needed treatment with h
igher doses of steroids than the patients positive for BP230 alone (P
< 0.05). Furthermore, all five recalcitrant cases, which did not respo
nd well to steroid treatment, were shown to possess autoantibodies aga
inst BP180 in their sera. Patients with antibodies to BP230 had a tend
ency to have a high titre of anti-BMZ antibodies (P < 0.005). These re
sults suggest that anti-BP180 antibodies may be more related to the di
sease severity than anti-BP230 antibodies.