TOXICITY OF CAMPHORATED PHENOL AND CAMPHORATED PARACHLOROPHENOL IN DENTAL-PULP CELL-CULTURE

The toxicity of phenol, parachlorophenol, camphorated phenol, camphora ted parachlorophenol, and camphor was evaluated using the 3-(4,5-dimet hylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric a ssay on established rat dental pulp cells (RPC-C24), RPC-C2A cells at the confluent stage were incubated for 24 h in an experimental medium containing each compound at different concentrations, All tested drugs showed cytotoxicity in the MTT assay in a concentration-dependent man ner, it is believed that camphor is a vehicle, and it reduces the toxi city of phenol and parachlorophenol. However, camphor itself showed-cy totoxicity, and the addition of camphor increased-the toxicity of phen ol and parachlorophenol, reconfirming the cytotoxicity of these classi cal antiseptics.