ANDRASTINS A-SIMILAR-TO-C, NEW-PROTEIN FARNESYLTRANSFERASE INHIBITORSPRODUCED BY PENICILLIUM SP FO-3929 .1. PRODUCING STRAIN, FERMENTATIONISOLATION, AND BIOLOGICAL-ACTIVITIES

Authors
OMURA S INOKOSHI J UCHIDA R SHIOMI K MASUMA R KAWAKUBO T TANAKA H IWAI Y KOSEMURA S YAMAMURA S
Citation
S. Omura et al., ANDRASTINS A-SIMILAR-TO-C, NEW-PROTEIN FARNESYLTRANSFERASE INHIBITORSPRODUCED BY PENICILLIUM SP FO-3929 .1. PRODUCING STRAIN, FERMENTATIONISOLATION, AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 49(5), 1996, pp. 414-417
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
5
Year of publication
1996
Pages
414 - 417
Database
ISI
SICI code
0021-8820(1996)49:5<414:AANFI>2.0.ZU;2-M
Abstract
New protein farnesyltransferase inhibitors, andrastins A similar to C, have been discovered in the cultured broth of Penicillium sp. FO-3929 . Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastin s A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 mu M, respectively.