NEW METABOLITES WITH NEMATOCIDAL AND ANTIMICROBIAL ACTIVITIES FROM THE ASCOMYCETE LACHNUM-PAPYRACEUM (KARST) KARST .8. ISOLATION, STRUCTUREDETERMINATION AND BIOLOGICAL-ACTIVITIES OF MINOR METABOLITES STRUCTURALLY RELATED TO MYCORRHIZIN-A

Five new minor metabolites, papyracon D (6), 6-O-methylpapyracon B (9) , 6-O-methylpapyracon C (10), lachnumfuran A (11) and lachnumlactone A (12a), together with the known chloromycorrhizinol A (4), have been i solated from extracts of the culture fluids of the ascomycete Lachnum papyraceum. The compounds, which structures were determined by spectro scopic methods, are structurally related to the nematicidal and antibi otic mycorrhizin A (1), which also is produced by the fungus. The nema ticidal, antibiotic and cytotoxic activities of the new compounds are weaker compared to those of mycorrhizin A (1); Papyracon D (6) possess es the highest antibiotic activities while lachnumlactone A (12a) is t he most nematicidal and cytotoxic.