REVERSIBLE OVULATORY FAILURE ASSOCIATED WITH THE DEVELOPMENT OF LUTEINIZED UNRUPTURED FOLLICLES IN WOMEN WITH INFLAMMATORY ARTHRITIS TAKINGNONSTEROIDAL ANTIINFLAMMATORY DRUGS
G. Smith et al., REVERSIBLE OVULATORY FAILURE ASSOCIATED WITH THE DEVELOPMENT OF LUTEINIZED UNRUPTURED FOLLICLES IN WOMEN WITH INFLAMMATORY ARTHRITIS TAKINGNONSTEROIDAL ANTIINFLAMMATORY DRUGS, British journal of rheumatology, 35(5), 1996, pp. 458-462
The case histories of three young women with ankylosing spondylitis, r
heumatoid arthritis and a seronegative inflammatory polyarthritis unde
rgoing investigations for infertility are presented. In each, non-ster
oidal anti-inflammatory drug (NSAID) therapy was associated with the r
ecurrent development of luteinized unruptured ovarian follicles and no
rmal ovulation following drug withdrawal. It is suggested that NSAID t
herapy may be an important and frequently overlooked cause of anovulat
ion and infertility.