SYNTHESIS AND BIOLOGICAL-ACTIVITY OF CONFORMATIONALLY RESTRICTED TRICYCLIC ANALOGS OF THE HORMONE MELATONIN

Authors
LECLERC V DEPREUX P LESIEUR D CAIGNARD DH RENARD P DELAGRANGE P GUARDIOLALEMAITRE B MORGAN P
Citation
V. Leclerc et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF CONFORMATIONALLY RESTRICTED TRICYCLIC ANALOGS OF THE HORMONE MELATONIN, Bioorganic & medicinal chemistry letters, 6(10), 1996, pp. 1071-1076
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
10
Year of publication
1996
Pages
1071 - 1076
Database
ISI
SICI code
0960-894X(1996)6:10<1071:SABOCR>2.0.ZU;2-X
Abstract
A serie of rotationally restricted tricyclic naphthalenic and tetrahyd ronaphthalenic analogs of the hormone melatonin has been synthesized, the C-7 oxygen being incorporated in a pyran, furan or dioxan heterocy clic ring. The receptor binding profile of these compounds is a functi on of the directionality of the lone pairs electrons of this C-7 oxyge n. In these two studied analogous series the agonist activity seems to be correlated with the existence of a naphthalene nucleus. (C) 1996 E lsevier Science Ltd