A TOPLISS TREE ANALYSIS OF THE HIV-PROTEASE INHIBITORY ACTIVITY OF 6-PHENYL-4-HYDROXY-PYRAN-2-ONES

Authors
STEINBAUGH BA HAMILTON HW PRASAD JVNV PARA KS TUMMINO PJ FERGUSON D LUNNEY EA BLANKLEY CJ
Citation
Ba. Steinbaugh et al., A TOPLISS TREE ANALYSIS OF THE HIV-PROTEASE INHIBITORY ACTIVITY OF 6-PHENYL-4-HYDROXY-PYRAN-2-ONES, Bioorganic & medicinal chemistry letters, 6(10), 1996, pp. 1099-1104
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
10
Year of publication
1996
Pages
1099 - 1104
Database
ISI
SICI code
0960-894X(1996)6:10<1099:ATTAOT>2.0.ZU;2-N
Abstract
In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV pro tease, a series of compounds were synthesized following the Topliss op erational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of compounds with polar substitue nts were made. (C) 1996 Elsevier Science Ltd