SYNTHESIS AND IN-VITRO CYTOTOXICITY OF CRYPTOPHYCINS AND RELATED ANALOGS

Authors
DEMUYS JM REJ R NGUYEN D GO B FORTIN S LAVALLEE JF
Citation
Jm. Demuys et al., SYNTHESIS AND IN-VITRO CYTOTOXICITY OF CRYPTOPHYCINS AND RELATED ANALOGS, Bioorganic & medicinal chemistry letters, 6(10), 1996, pp. 1111-1116
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
10
Year of publication
1996
Pages
1111 - 1116
Database
ISI
SICI code
0960-894X(1996)6:10<1111:SAICOC>2.0.ZU;2-1
Abstract
Several members of the Cryptophycin family were synthesised using a st raightforward convergent approach, The proposed synthetic route was us ed to prepare novel analogs of Cryptophycins A and B in which the benz ylic epoxide moiety was replaced by alternate electrophilic functions. The effect of these modifications on cytotoxic activity was determine d on several tumor cell lines. (C) 1996 Elsevier Science Ltd