SUPPRESSION OF MORPHINE AND COCAINE SELF-ADMINISTRATION IN RATS BY A MIXED MU-ANTAGONIST KAPPA-AGONIST (N-CBM-TAMO) AND A LONG-ACTING SELECTIVE D-1 ANTAGONIST (AS-300)

Authors
ARCHER S GLICK SD MAISONNEUVE IM BIDLACK JM XU JY TEITLER M SEBASTIAN A ELHAMOULY W HUTCHINSON I
Citation
S. Archer et al., SUPPRESSION OF MORPHINE AND COCAINE SELF-ADMINISTRATION IN RATS BY A MIXED MU-ANTAGONIST KAPPA-AGONIST (N-CBM-TAMO) AND A LONG-ACTING SELECTIVE D-1 ANTAGONIST (AS-300), Bioorganic & medicinal chemistry letters, 6(10), 1996, pp. 1139-1144
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
10
Year of publication
1996
Pages
1139 - 1144
Database
ISI
SICI code
0960-894X(1996)6:10<1139:SOMACS>2.0.ZU;2-M
Abstract
N-CBM-TAMO 2 was prepared by the same procedure as used for TAMO 1. It was found to be a short-term kappa agonist and along-term mu antagoni st. The benzazepine 12, (AS-300) was a potent selective D-1 antagonist . Both compounds suppressed cocaine and morphine self-administration i n rats at doses which did not affect water consumption. (C) 1996 Elsev ier Science Ltd