SYNTHESIS AND SAR OF DIIODOTYROSINE-DERIVED GLYCINE-SITE N-METHYL-D-ASPARTATE RECEPTOR LIGANDS

Authors
CURTIS NR KULAGOWSKI JJ LEESON PD MAWER IM RIDGILL MP ROWLEY M GRIMWOOD S MARSHALL GR
Citation
Nr. Curtis et al., SYNTHESIS AND SAR OF DIIODOTYROSINE-DERIVED GLYCINE-SITE N-METHYL-D-ASPARTATE RECEPTOR LIGANDS, Bioorganic & medicinal chemistry letters, 6(10), 1996, pp. 1145-1150
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
10
Year of publication
1996
Pages
1145 - 1150
Database
ISI
SICI code
0960-894X(1996)6:10<1145:SASODG>2.0.ZU;2-F
Abstract
A series of analogues of the novel diiodotyrosine derived NMDA glycine -site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the alpha-amino acid function, having the (R) absolute stereochemistry, the 3,5-diiodo substituted aromatic ring and a lipop hilic group attached at the phenolic oxygen of the tyrosine moiety. (C ) 1996 Elsevier Science Ltd