DIPEPTIDE MIMETICS CAN SUBSTITUTE FOR THE RECEPTOR ACTIVATION DOMAIN RESULTING IN HIGHLY POTENT ANALOGS OF HPTH(1-36) FRAGMENT

Authors
WAELCHLI R GAMSE R BAUER W MEIGEL H LIER E FEYEN JHM
Citation
R. Waelchli et al., DIPEPTIDE MIMETICS CAN SUBSTITUTE FOR THE RECEPTOR ACTIVATION DOMAIN RESULTING IN HIGHLY POTENT ANALOGS OF HPTH(1-36) FRAGMENT, Bioorganic & medicinal chemistry letters, 6(10), 1996, pp. 1151-1156
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
10
Year of publication
1996
Pages
1151 - 1156
Database
ISI
SICI code
0960-894X(1996)6:10<1151:DMCSFT>2.0.ZU;2-W
Abstract
A series of hPTH(1-36) analogues were prepared to study the role of th e first peptide bond between residues Ser(1)-Val(2). Some of these ana logues were found to show high affinity binding in intact opossum kidn ey (OK-1) cells and were very active in their ability to stimulate ade nylate cyclase production in intact OK-1 cells, rat UMR106-06 osteosar coma cells, and SaOS-2 human osteosarcoma cells. (C) 1996 Elsevier Sci ence Ltd