THYMOPENTIN IN SOLID LIPID NANOPARTICLES

The pentapeptide thymopentin was englobed in solid lipid nanoparticles prepared from warm microemulsions following two different methods: fr om O/W microemulsion by forming the more lipophilic ion-pair with hexa decylphosphate, and from W/O/W microemulsion by dissolving the pentape ptide in the aqueous internal phase. The incorporation of the hydrophi lic drug was 5.2% and 1.7% respectively; in both cases, the in vitro r elease of thymopentin from the solid lipid nanoparticles followed a ps eudo-zero-order kinetics.