PREPARATION OF SUPEROXIDE-DISMUTASE ENTRAPPED IN CERAMIDE-CONTAINING LIPOSOMES FOR ORAL-ADMINISTRATION

Ceramides and distearoylphosphatidylcholine (DSPC) were incorporated i n various liposomes preparations in comparison with dipalmitoylphospha tidylcholine alone. Preparations were introduced in an 'Artificial Sto mach-Duodenum' model to improve their stability. Better results were o bserved for DSPC and ceramide-containing liposomes. Entrapment of Cu-Z n Superoxide dismutase (SOD) in liposomes have been carried out for or al administration. The efficiency of entrapment of SOD was 35.4% for l iposomes without ceramides, and from 24.3% to 46.1% for ceramide-conta ining liposomes.