CORRELATION OF PHARMACOLOGICAL PROPERTIES OF A GROUP OF HYPOLIPAEMIC DRUGS BY MOLECULAR TOPOLOGY

This investigation was undertaken to test the ability of the molecular connectivity model to predict the percentage of plasma protein bindin g, the percentage of total cholesterol reduction and oral LD50 in rats of a group of hypolipaemic drugs using multi-variable regression equa tions with multiple correlation coefficients, standard error of estima te, degrees of freedom, F-Snedecor function values, Mallow's CP and St udent's t-test as criteria of fit. Regression analyses showed that the molecular connectivity model predicts these properties. Corresponding stability (cross validation) studies were made on the selected predic tion models which confirmed their goodness of fit. The results also de monstrated that the presence of substituents and molecular volume, det ermine the value of these properties in hypolipaemic drugs.