Jh. Guo et Km. Cooklock, THE EFFECTS OF BACKING MATERIALS AND MULTILAYERED SYSTEMS ON THE CHARACTERISTICS OF BIOADHESIVE BUCCAL PATCHES, Journal of Pharmacy and Pharmacology, 48(3), 1996, pp. 255-257
The effects of backing materials (ethylcellulose, polyvinylpyrrolidone
and cellulose acetate mixture, and poly(ethylene-co-vinyl acetate) on
the characteristics (hydration and adhesion) of newly developed bioad
hesive patches for controlled drug delivery via the buccal mucosa were
investigated. It was found that the swelling profiles of buccal patch
es were changed dramatically by the species and amount of the backing
materials, and those changes could alter the drug release profile. The
drug release profiles of single-layered and multilayered buccal patch
es were significantly different. It was demonstrated that the multiple
-layer device could be used to modify the drug release for obtaining t
he ideal clinical pharmacokinetic release profile.