D. Ruggero et P. Londei, DIFFERENTIAL ANTIBIOTIC-SENSITIVITY DETERMINED BY THE LARGE RIBOSOMAL-SUBUNIT IN THERMOPHILIC ARCHAEA, Journal of bacteriology, 178(11), 1996, pp. 3396-3398
Hybrid ribosomes obtained by mixing the ribosomal subunits of the extr
emely thermophilic archaea Sulfolobus solfataricus and Desulfurococcus
mobilis were tested for their sensitivity to selected antibiotics. It
is shown that structural differences in the large ribosomal subunits
determine qualitatively and quantitatively the patterns of response to
alpha-sarcin and paromomycin in these species.