SUPPORT FOR FOUNDER EFFECT FOR 2 LIPOPROTEIN-LIPASE (LPL) GENE-MUTATIONS IN FRENCH-CANADIANS BY ANALYSIS OF GT MICROSATELLITES FLANKING THELPL GENE

Authors
WOOD S SCHERTZER M HAYDEN M MA YH
Citation
S. Wood et al., SUPPORT FOR FOUNDER EFFECT FOR 2 LIPOPROTEIN-LIPASE (LPL) GENE-MUTATIONS IN FRENCH-CANADIANS BY ANALYSIS OF GT MICROSATELLITES FLANKING THELPL GENE, Human genetics, 91(4), 1993, pp. 312-316
Citations number
26
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
91
Issue
4
Year of publication
1993
Pages
312 - 316
Database
ISI
SICI code
0340-6717(1993)91:4<312:SFFEF2>2.0.ZU;2-2
Abstract
Mutations in the human lipoprotein lipase (LPL) gene are one of the ma jor causes of familial chylomicronemia. We have characterized two poly morphic GT microsatellites flanking this gene. Two LPL mutations that are extremely frequent in French Canadians appear to be in complete li nkage disequilibrium with specific LPL microsatellite haplotypes indic ating a founder effect within this population.