PRESENTATION OF PEPTIDE ANTIGENS AS ALBUMIN CONJUGATES FOR USE IN DETECTION OF SERUM ANTIBODIES BY ENZYME-LINKED-IMMUNOSORBENT-ASSAY

The use of linear peptides as antigens for detection of serum antibodi es has been studied using a sequence of the Borrelia burgdorferi prote in, flagellin, and Lyme disease sera as a model, It was found that a n ovel presentation of the peptide as a hapten on the carrier protein, b ovine serum albumin, in the enzyme-linked immunosorbent assay format c an be successfully applied to distinguish between Lyme disease and con trol sera.