CONDENSED 1,2,4-TRIAZINES - SYNTHETIC AND MOLECULAR MODELING STUDIES OF ,8-DIHYDRO-7-METHYLPYRAZINO[2,3-E]-1,2,4-TRIAZINES

Authors
TZENG CC LEE KH CHEN YL WANG TC
Citation
Cc. Tzeng et al., CONDENSED 1,2,4-TRIAZINES - SYNTHETIC AND MOLECULAR MODELING STUDIES OF ,8-DIHYDRO-7-METHYLPYRAZINO[2,3-E]-1,2,4-TRIAZINES, Heterocycles, 43(5), 1996, pp. 1007-1013
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
43
Issue
5
Year of publication
1996
Pages
1007 - 1013
Database
ISI
SICI code
0385-5414(1996)43:5<1007:C1-SAM>2.0.ZU;2-3
Abstract
,8-Dihydro-7-methylpyrazino[2,3-e]-1,2,4-triazines (dihydroazapteridin es) were prepared by Hinsberg reaction of 5,6-diamino-1,2,4-triazines with bromoacetone via a regiospecific fashion. The initial Z-form Schi ff base intermediates cyclized to give ,6-dihydro-7-methylpyrazino[2,3 -e]-1,2,4-triazines which underwent pi redistribution to afford ,8-dih ydro-7-methylpyrazino[2,3-e]-1,2,4-triazines as final products.