ASYMMETRIC-SYNTHESIS OF BENZYLIC QUATERNARY CARBON CENTER VIA AN ENZYMATIC-REACTION

Authors
SHIOTANI S OKADA H NAKAMATA K YAMAMOTO T SEKINO F
Citation
S. Shiotani et al., ASYMMETRIC-SYNTHESIS OF BENZYLIC QUATERNARY CARBON CENTER VIA AN ENZYMATIC-REACTION, Heterocycles, 43(5), 1996, pp. 1031-1047
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
43
Issue
5
Year of publication
1996
Pages
1031 - 1047
Database
ISI
SICI code
0385-5414(1996)43:5<1031:AOBQCC>2.0.ZU;2-T
Abstract
(R)-(+)-((R)-(+)-12) and l-1-methyl-7-methoxy-1,2,3,4-tetrahydronaphth alene ((S)-(-)-12) were synthesized based on enantioselective PLE hydr olysis of diethyl 2-(m-methoxyphenyl)-2-methylmalonate. From (R)-(+)-1 2, (+)-O-Methylaphanorphine (16) and (-)-aphanorphine were synthesized . tyl-N-methylaminoethyl)-1-methyl-7-methoxytetralin (25) was synthesi zed from (S)-(-)-12. This transformation constitutes a formal synthesi s of (-)-eptazocine.