(R)-(+)-((R)-(+)-12) and l-1-methyl-7-methoxy-1,2,3,4-tetrahydronaphth
alene ((S)-(-)-12) were synthesized based on enantioselective PLE hydr
olysis of diethyl 2-(m-methoxyphenyl)-2-methylmalonate. From (R)-(+)-1
2, (+)-O-Methylaphanorphine (16) and (-)-aphanorphine were synthesized
. tyl-N-methylaminoethyl)-1-methyl-7-methoxytetralin (25) was synthesi
zed from (S)-(-)-12. This transformation constitutes a formal synthesi
s of (-)-eptazocine.