G. Heinisch et al., SYNTHETIC BUILDING-BLOCKS CONTAINING THE 1,2-DIAZINE MOIETY - N-PROTECTED AND O-PROTECTED 3-(4-PYRIDAZINYL)ISOSERINES, Heterocycles, 43(5), 1996, pp. 1057-1071
The synthesis of pyridazinylglycidates and pyridazinylimines as potent
ial precursors of pyridazinylisoserine derivatives, is described. Reac
tion of the imines (6a,b) with alpha-silyloxyketene acetals in the pre
sence of zinc chloride led to isoserine derivatives (7a,b) and (8a,b).
The mixtures of diastereoisomers obtained were separated and configur
ations were determined by X ray analysis.