SYNTHETIC BUILDING-BLOCKS CONTAINING THE 1,2-DIAZINE MOIETY - N-PROTECTED AND O-PROTECTED 3-(4-PYRIDAZINYL)ISOSERINES

Authors
HEINISCH G LANGER T TONNEL J MEREITER K WURST K
Citation
G. Heinisch et al., SYNTHETIC BUILDING-BLOCKS CONTAINING THE 1,2-DIAZINE MOIETY - N-PROTECTED AND O-PROTECTED 3-(4-PYRIDAZINYL)ISOSERINES, Heterocycles, 43(5), 1996, pp. 1057-1071
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
43
Issue
5
Year of publication
1996
Pages
1057 - 1071
Database
ISI
SICI code
0385-5414(1996)43:5<1057:SBCT1M>2.0.ZU;2-9
Abstract
The synthesis of pyridazinylglycidates and pyridazinylimines as potent ial precursors of pyridazinylisoserine derivatives, is described. Reac tion of the imines (6a,b) with alpha-silyloxyketene acetals in the pre sence of zinc chloride led to isoserine derivatives (7a,b) and (8a,b). The mixtures of diastereoisomers obtained were separated and configur ations were determined by X ray analysis.