THE PSYCHO-NEURO-IMMUNE-ENDOCRINE RESPONSE - A PHYSIOLOGICAL AND PATHOLOGICAL WAY OF LIFE

It is proposed that the response of the organism to injury by mechanic al energy is made up of three consecutive phases: an immediate or nerv ous phase, an intermediate or immune phase and a late or endocrine pha se. The functions that characterize each one of these three phases cou ld represent the activity of the functional nervous, immune and endocr ine systems. This functional concept of the psycho-neuro-immune-endocr ine system could make it possible to integrate biochemical knowledge i nto the organism response to injury.