A COMPARATIVE EXPERIMENTAL-STUDY OF SILICONE GEL AND BIOPLASTIQUE

Bioplastique, a biphasic polymer of textured dimetylpolysiloxane is re ported to be useful in filling small soft tissue defects. The micropar ticles range in size from 100 to 600 mu and are suspended in a hydroge l carier from the family of the plasdones. The bioexcretable gel compo nent is rapidly phagocytized and replaced by fibrin-like matrix with i n a few days. In this study it is aimed to observe the local and syste mic effects of Bioplastique and gel silicone in comparison. Our study in rabbit ears has shown that Bioplastique caused severe foreign body reaction in injection site and showed no migration to lymph nodes. On the other hand, silicone gel caused fibrous encapsulation and showed m igration to lymph nodes, and formation of granulomatous reaction.