Objectives. Priapism in the pediatric population is rare and most comm
only occurs secondary to sickle cell disease or hematologic malignancy
. We present a case of a 12-year-old boy with priapism who required ag
gressive surgical therapy for adequate detumescence. This patient had
a recent viral upper respiratory infection and titers for Mycoplasma p
neumoniae were indicative of infection. We propose that a hypercoagula
ble state was induced by the M. pneumoniae infection, which resulted i
n the priapism. Methods. A 12-year-old boy with a recent upper respira
tory illness presented to his pediatrician with priapism. After failin
g conservative management, the patient ultimately required a surgical
shunt for detumescence. Serum was sent to detect antibodies against M.
pneumoniae. Results. The child failed to respond to corporeal irrigat
ions and bilateral Winter shunts. He underwent an El-Ghorab procedure
the following morning, which resulted in a flaccid penis. Serum M. pne
umoniae anti bodies were detected and indicated moderate infection. Co
nclusions. We propose that this 12-year-old boy had priapism secondary
to infection with M. pneumoniae. M. pneumoniae infection can produce
a hypercoagulable state, especially in selected areas of the circulati
on. This is the first reported case of priapism associated with M. pne
umoniae.