Metastases of signet ring cell carcinomas to the scrotum are rare, We
present 2 patients with this kind of tumor. In 1 patient, the scrotal
pathologic examination helped to detect an adenocarcinoma of the appen
dix with a signet ring cell component, with an extent that had not bee
n apparent clinically. The other patient was seen at an advanced stage
of signet ring cell carcinoma of the sigmoid colon following surgical
therapy and palliative chemotherapy. The route of metastases seems to
be via seeding along the testicular cord and via lymphatic disseminat
ion.