REOVIRUS TYPE-1 ASSOCIATED WITH MENINGITIS

A previously healthy 3-month-old girl presented with symptoms of menin gitis, diarrhoea, vomiting and fever, Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like parti cles by electron microscopy. RNA-gel electrophoresis, immunofluorescen ce and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of pa ired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovi rus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.