EPSTEIN-BARR-VIRUS INFECTION ASSOCIATED WITH INTERSTITIAL NEPHRITIS AND CHRONIC FATIGUE

Severe renal disease in the setting of Epstein-Barr virus (EBV) infect ion is exceedingly rare. We report here the case of a 22-year-old man with acute EBV infection associated with severe interstitial nephritis . The patient developed chronic fatigue and chronic renal failure with a serological profile typical of primary EBV infection. Clinical impr ovement with anti-EBNA seroconversion occurred after acyclovir therapy . Our patient illustrates that chronic fatigue with major organ dysfun ction and a serological profile of primary infection can be seen in ch ronic EBV infection. In such a case, acyclovir may prove beneficial.