MICROSPHERES BASED DETOXIFICATION SYSTEM - A NEW METHOD IN CONVECTIVEBLOOD PURIFICATION

A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous into xications, are removed poorly by conventional detoxification methods b ecause of low accessibility (hemodialysis), insufficient adsorption ca pabilities (hemosorption), low efficiency (peritoneal dialysis), or ec onomic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based syste m was designed. Major operating parameters of the latter can be modifi ed to allow for adjustment to individual clinical situations. An extra corporeal blood circuit including a plasmafilter is combined with a se condary high-velocity plasma circuit driven by a centrifugal pump. Dif ferent microspheric adsorbers can be combined in one circuit or applie d in sequence. Thus, a prolonged treatment can be tailored using speci ally designed selective adsorber materials, Comparing this system with existing methods (high-flux hemodialysis I molecular adsorbent recycl ing system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.