A 29-year-old woman with coronary risk factors presented with nonexert
ional atypical burning chest pain of 1 week's duration. A myocardial p
erfusion study with Tc-99m MIBI revealed a severe stress induced anter
oseptal perfusion defect that completely reperfused on a subsequent re
sting Tc-99m MIBI study. Coronary angiography showed mild nonobstructi
ve coronary artery disease. At the termination of the procedure, a spo
ntaneous episode of burning chest pain occurred. Left main coronary ar
tery reinjection of contrast revealed proximal diffuse left anterior d
escending coronary artery spasm. The patient was followed for 2 years
with no further episodes of chest pain, while on calcium channel-block
er medication. The phenomenon of vasospastic angina and the role of my
ocardial perfusion scintigraphy is discussed.