AUTOANTIBODIES AGAINST MDA-LDL IN SUBJECTS WITH SEVERE AND MINOR ATHEROSCLEROSIS AND HEALTHY POPULATION-CONTROLS

Autoantibodies against oxidized low-density lipoprotein (LDL) have bee n reported to be associated with atherosclerosis. However, data are no t consistent. We compared the titres of autoantibodies to malondialdeh yde-modified LDL in three groups, a case group with angiographically d ocumented severe coronary stenosis (> 80% stenosis in at least 1 vesse l, n = 47), a hospital control group with minor stenosis on the corona ry angiography (< 50% stenosis in all three major vessels, n = 47) and a healthy population control group with no history of coronary heart disease (n = 49). Age ranged from 26 to 68 years. Subjects were freque ncy-matched for gender distribution and storage time of the blood samp les. No relevant differences in autoantibody titre between case and co ntrol groups were found. The mean autoantibody titres (+/- S.D.) were 1.44 +/- 1.82, 1.46 +/- 1.40 and 1.62 +/- 1.95 for cases, hospital con trols and population controls, respectively. No correlations were foun d between autoantibody titre and age, number of cigarettes smoked and LDL or total cholesterol. Autoantibody titres were correlated with bod y mass index (r = 0.2) and high-density lipoprotein (HDL) (r = - 0.2). Odds ratios (OR) were calculated by tertiles of autoantibody titres f or the hospital control group and the population control group, respec tively. Age-adjusted OR (95% confidence interval) for medium and high compared to low autoantibody titre were 0.76 (0.27-2.14) and 1.09 (0.3 9-2.95) for the comparison between cases and hospital controls and 1.0 9 (0.39-3.07) and 0.90 (0.32-2.56) for the comparison between cases an d population controls. Adjustment for gender, body mass index, smoking habits and HDL yielded essentially the same results. This study does not support an association between autoantibody titres to oxidized LDL and the extent of coronary stenosis.