LATE BIOPROSTHETIC VALVE ENDOCARDITIS CAUSED BY PHIALEMONIUM AFF CURVATUM AND STREPTOCOCCUS-SANGUIS - A CASE-REPORT

Dual fungal and Streptococcus sanguis endocarditis is reported in a 63 -year-old woman 7 months after placement of a porcine aortic valve pro sthesis. Both microorganisms were isolated by blood cultures, and the patient succumbed after a full course of antibacterial chemotherapy wi thout having received antifungal chemotherapy. The best possible desig nation of the fungus was Phialemonium aff. curvatum W. Gams & W. B. Co oke, as represented by CBS 331.93. At autopsy hyphae were revealed in the porcine valve tissue by conventional staining. A hyperimmune rabbi t antiserum raised towards strain CBS 331.93 and extensively absorbed with heterologous fungal antigens reacted strongly with hyphae in the valve tissue by indirect immunofluorescence technique. We consider it most likely that the Phialemonium infection evolved insidiously from t he time of open heart surgery and led to a haematogenous streptococcal infection of a more fulminant course.