CANDIDA-ALBICANS STRESS MANNOPROTEIN, SMP200, ENHANCES TUMOR-NECROSIS-FACTOR SECRETION IN THE MURINE MACROPHAGE CELL-LINE ANA-I

Authors
PITZURRA L POLONELLI L CANTELLI C GERLONI M PONTON J BIKANDI J BLASI E
Citation
L. Pitzurra et al., CANDIDA-ALBICANS STRESS MANNOPROTEIN, SMP200, ENHANCES TUMOR-NECROSIS-FACTOR SECRETION IN THE MURINE MACROPHAGE CELL-LINE ANA-I, Journal of medical and veterinary mycology, 34(3), 1996, pp. 219-222
Citations number
15
Categorie Soggetti
Mycology
Journal title
Journal of medical and veterinary mycology → ACNP
ISSN journal
02681218
Volume
34
Issue
3
Year of publication
1996
Pages
219 - 222
Database
ISI
SICI code
0268-1218(1996)34:3<219:CSMSET>2.0.ZU;2-W
Abstract
Tumour necrosis factor (TNF) secretory activity has been studied in th e murine macrophage cell line ANA-1 following in vitro exposure to Can dida albicans 200 kDa stress mannoprotein (SMP200). Treatment of ANA-1 murine macrophages with 200 kDa stress mannoprotein results in increa sed TNF secretion. The phenomenon is (i) dose- and time-dependent, (ii ) abrogated by 200 kDa stress mannoprotein preincubation with a specif ic monoclonal antibody, and (iii) dependent on intact murine macrophag e Ca2+/calmodulin-dependent protein kinase function.