T. Josephhorne et al., AMPHOTERICIN-B RESISTANT ISOLATES OF CRYPTOCOCCUS-NEOFORMANS WITHOUT ALTERATION IN STEROL BIOSYNTHESIS, Journal of medical and veterinary mycology, 34(3), 1996, pp. 223-225
Amphotericin B resistant mutants of Cryptococcus neoformans were isola
ted accumulating mainly ergosterol. Cross-resistance to azole antifung
als was not observed. Together with previous data this indicates that
at least three categories of amphotericin B resistance can arise: ster
ol mutants, amphotericin B and azole cross-resistant mutants and ampho
tericin B resistant mutants with no azole cross-resistance.