SOLID-STATE FORMATION OF AN INCLUSION COMPOUND OF CHOLIC-ACID WITH P-TOLUIDINE

Cholic acid undergoes solid-solid reactions with some aromatic molecul es to form inclusion compounds. Simple shaking of a mixture of powdere d cholic acid and p-toluidine results in formation of the 1:1 (host:gu est) inclusion compound which has the same Structure as that formed by conventional crystallization methods: monoclinic space group P2(1) wi th a = 13.577(4), b = 8.078(2), c = 14.182(6) Angstrom, beta = 114.42( 3)degrees, Z = 2 and R(1) = 0.061 for 2680 unique reflections.